Su Qingyan, a modern medical genius, traveled through the "Shen Nong Space" and became the unpopular daughter of the Prime Minister's Palace in Dajing. She married the dying regent Xiao Jingyuan on behalf of her half-sister Shen Ruoyao. She combined the unique skills of Chinese and Western medicine with the power of space to help Xiao Jingyuan detoxify and prolong his life. The two went from being on guard to forming an alliance. During this period, Shen Ruoyao, who was obsessed with Xiao Jingyuan, was framed repeatedly. The eldest prince Xiao Jingyu, who admired Su Qingyan, became an obstacle but could not succeed. Coupled with the emperor's power checks and family conspiracies, dangers were everywhere. Su Qingyan became famous for her medical skills, breaking the plague, investigating the source of the virus, and stabilizing the rear. Xiao Jingyuan led the army to quell the chaos and eliminate the traitors. The two worked together to resolve the turmoil in the court and the conspiracy in the house. In the end, they eliminated the hostile forces, helped their young nephew ascend the throne, implemented new policies to benefit the people, and later returned to the government to travel and use their medical skills to help the world, creating a legend of knowing each other and staying together across time and space.