The "Great Annihilation" disaster broke out, and 90% of the world's population mutated into strange creatures. Existing civilization collapsed and cities were reduced to ruins. Highways became the only passage connecting the survivors' strongholds, but they were shrouded in strange fog, space distortion, and mutated strange things. The remaining humans awaken the "sequence mark" and can unlock the sequence ability by absorbing the strange core. At the same time, when materials come into contact with the sequence energy, they can trigger "upgrade mutations", forming the two core pillars for survival in the apocalypse.