Bai Zhi, the successor of modern Chinese medicine, traveled through time and became a concubine in the cold palace who was pregnant with Liujia and was falsely accused of having an affair. Relying on her unique skills of medicine and poison, she saves herself and protects her fetus, secretly saves the palace people and accumulates connections, and outsmarts the fatal situation. Emperor Xiao Zeyuan surrendered to the cold palace and was impressed by his medical skills and character. After a thorough investigation of the unjust case, he welcomed him back to the palace. Bai Zhi uses her medical skills as a blade to deal with the poisonous concubines in the harem and the machinations of her relatives, protect her young son, bring peace to the court, and finally makes her stepmother the queen of the world, creating a legend of the counterattack of a generation of medical concubines.