Jiang Shenghun, a modern medicine student, was transformed into a concubine from the general's palace with a "drug residue" brand on her feet, and was forced to marry Xiao Lin, the third prince who was dying of poisoning. On the wedding night, she faces the dilemma of "revealing her medical skills to save her husband" or "immediately burying him if he doesn't save her". In order to survive and investigate the unjust case of her biological mother, she relied on modern medical knowledge, acupuncture, penicillin, first aid, etc. As weapons to deal with the emperor Xie Heng who wanted to kill her and various forces in the palace. She uncovered the emperor's list to save the Queen Mother, broke the poison formation, and tested medicine on her own. Amidst repeated "witchcraft" accusations and life-and-death crises, she exposed Xie Heng's crimes of running a "Medicine Man's Cave" and collaborating with the enemy and treason, and also implicated the complicated blood relationship between herself and Xiao Lin. In the end, Jiang Sheng not only rescued Xiao Lin and rehabilitated the family, but also took charge of the imperial hospital as a "drug scum", abolished the medical ban and established a women's hall, sowing the fire of modern medicine in ancient times, and completed a counterattack from a "Yao Yin" who was waiting for death to the leader of a generation of medical politics.