Shen Jinghong, the legitimate daughter of the Duke of Zhenguo, was proficient in the art of poison in her previous life but had a love brain. After assisting the crown prince to ascend the throne, she was betrayed by her concubine and was given the opportunity to poison her to death in the cold palace. Reborn back to the age of 16, she activated the Poison Abyss space, used her unique skills of medicine and poison to tear apart her stepmother Liu Shi, kicked White Lotus's concubine Shen Rouwei, and domineeringly broke off the engagement with the scumbag prince. Xiao Jue, the regent, encounters a bewitched man by chance at a royal hunting ground, and forms an alliance with half an antidote. He uses his poison skills to solve the court witchcraft case and the Queen Mother's strange poison, and is awarded the title of "Lord of Jinghong County". She teamed up with Xiao Jue to reveal the truth about her mother's murder, quelled the rebellion of the second prince, and finally made a comeback from the infamous legitimate daughter to the empress of the world, creating a legend of monogamy between the emperor and the empress.