Su Qingyuan, a master of modern poison medicine, traveled through time and became the legitimate daughter of the Duke of Zhenguo of the Dajing Dynasty in the Xuanling Continent. The original owner was framed by his cousin Su Qingrou and her fiancé, Prince Xiao Jingyuan, and died tragically in a mass grave. After Su Qingyuan was reborn, she relied on her unique abilities as a doctor and poisoner to seek revenge, vowing to make everyone who had insulted her original owner pay with their blood, and eventually became the world-famous poisonous concubine.