Lu Yao, the direct disciple of the medical sage, became obsessed with practicing martial arts and needed a rhinoceros horn to survive. He held a betrothal jade pendant and approached the powerful Prime Minister Su Huai, who was known as the "treacherous minister". At that time, Su Huai was poisoned by the strange Miao poison "Yanhua" and was looking for a successor to the medical saint. The two of them agreed to the engagement with their own motives, starting an extreme pull to exploit each other. When the fight for the soul horn, the solution to the poisonous "Yanhua" intertwined with the major conspiracy case, Su Huai was willing to trade Lu Yao's life with his life, and Lu Yao also put aside his grudges to cut his back and remove the poison. In the end, the two teamed up to put down the rebellion, Su Huai cleared his name as a "treacherous minister", and Lu Yao got his spiritual horn to save his life. This love that started with exploitation eventually became a fateful bond that went both ways.