During the founding period of the Da Qi Dynasty, Yun Xi, a descendant who lived in seclusion in the Medicine Valley, went down the mountain to the prosperous city of Yangzhou in search of medicinal materials to treat the plague. She rescued the mother of Shen Muyan, the prefect of Yangzhou, at a free clinic on the street, but was excluded by the drug dealer because she did not understand the market rules. When a plague broke out in Yangzhou, drug dealers were hoarding. Yun Xi used the secret recipe of Yaogu to develop an antidote, and joined forces with Shen Muyan to combat hoarding, established Huimin Pharmacy, and passed on Yaogu's medical skills.