During the Tianqi period in the late Ming Dynasty, Shen Qingyue, the female shopkeeper of Baicaotang in Jiangnan, had excellent medical skills and was good at detoxification. A strange disease breaks out in the local area, the patient's limbs become stiff, and the government is helpless. Shen Qingyue discovered that the cause of the disease was that the water source was poisoned, and developed an antidote to treat the people for free. The poisoner was actually a local medicinal material dealer who wanted to monopolize the medicinal material market. Shen Qingyue united with honest officials to collect evidence to expose the conspiracy, successfully subdued the criminals, and protected the health of the people in Jiangnan.