Ye Shuning, a descendant of a family with expertise in medicine and poisoning, had a kind heart and helped the world by hanging a pot to help the world. However, because he was unwilling to refine forbidden medicine for a traitor, his entire family was exterminated. He himself had his hand tendons cut off and was thrown into a poisonous cave, where he died of torture. A lingering soul lingered on, and she was reborn at the age of fifteen. At that time, she had just learned the essence of medicine and poison, her family was still there, and the traitorous officials had not yet come to her door. This time, she put away her kindness, used poison to protect her body, used medicine to save people, formed good relationships, and established power. She first protected the Ye family, and then planned every step to make the traitorous minister poisoned by strange poisons, making life worse than death, and destroyed his whole family with her own hands. She walked between the rivers and lakes and the court, rescued loyal people, poisoned and killed traitors, and became the "Mr. Shu Ning" that everyone respected. She finally settled her grudges and lived a happy life.