Medical prodigy Gu Yunxiang wakes up in the body of a countrywoman. The moment she opens her eyes, she finds herself abandoned by her husband in a dilapidated temple. The original owner was sold off as a bride to bring good fortune after being accused of theft. Her husband's family is ailing: her husband suffers from a leg condition and is also sickly. Everyone says he is mild-mannered, but only Gu Yunxiang knows how calculating he is beneath the surface, a cold-blooded and obsessive yandere.
Gu Yunxiang only wants to get away from her husband, return to her old profession, develop miracle medicines, and heal people. Instead, her yandere husband forcefully ties himself to her. She uses the medical knowledge from her past life to treat the sick and save lives, building a medical empire. Meanwhile, he advances his plans step by step, rising from a cripple to a man with power over the entire court.
“Madam, my headache is acting up. How about sharing a pillow with me tonight?”
Gu Yunxiang puts a hand to her forehead. “I thought you were supposed to be cold and heartless?”
“Madam, you want to leave me and start over in another life? Dream on! The only way you can do that is if you give up practicing medicine for the rest of your life!”
The obsessive chief minister presses her at every turn, leaving her no choice but to pull him into her world. They go from using each other to saving each other. She heals his body, but he heals her cold heart.