Mo Wuchen, the last descendant of the Five Poison Sect, was tired of the bloodshed in the world and lived in seclusion in the mountains with the "Poison Classic" which records the world's strange poisons and antidotes. He just wants to be at peace with the world, turn his poisonous skills into medical skills, and redeem his past sins. However, a sudden attack of strange poison broke all his peace! As the Poison King, he was actually poisoned silently, which in itself was the greatest provocation and irony to him.
In order to trace the source of the poison and save himself, Mo Wuchen was forced to reenter the world. He discovered that an unprecedented "poison conspiracy" was breaking out in the martial arts world. Masters from various sects were mysteriously poisoned with strange symptoms, but the spearheads were all pointed at him - the former "Five Poison Cult Successor"! For a time, he was reduced from a victim to a target of public criticism, and became the "murderer" hunted by the entire martial arts world.
During the escape and investigation, Mo Wuchen discovered that this was not a simple poisoning, but an ancient and secret "poison technique", behind which there was a shocking trap that subverted the martial arts structure. He used poison to fight poison and poison to transform into medicine. He not only saved countless innocent people who were poisoned, but also gradually won the trust of some people in the world. He transformed from the "Poison King" that everyone shouted to beat to the "Poison Doctor who saves the world". However, as the truth was peeled back layer by layer, Mo Wuchen was shocked to discover that the mastermind behind all this was actually closely related to the "betrayal of the truth" of the Five Poison Sect recorded on the last page of the "Poison Scripture"!