When Gu Yunzheng, a 21-year-old orthopedic genius, jumped to graduate school with an IQ far above ordinary people, but had a "negative score" in worldly sophistication; he met Lu Chenzhou, a 32-year-old Fortune 500 executive, an elite who controlled everything with absolute rationality and rules, in an unexpected "car accident." The doctor-patient relationship that began with "humeral fracture" gradually evolved into a fierce game between reason and instinct, rules and sincerity. One of them calmly held a knife on the operating table, and the other was strategizing in business negotiations, but in the end, they found the only "cause" that could cause their heartbeats to become disordered in each other's worlds.