Yun Shu, a cold-blooded doctor who specializes in medicine and poison, stepped into the troubled times with his secret skills, and accidentally got involved in the battle of regent Xiao Jue to cure the poison. The bone-corroding poison is always with us, and the shady plot of Wu Xun in the Miao border is approaching step by step. Fire jade, ice lotus, and water soul are scattered in all directions, becoming the key to breaking the situation. The ancient village was frightened, the Tusi Mansion formed an alliance, and the Black Wind Gorge fought to the death. Yun Shu used silver needles to fend off the enemy and the jade flute to break the poison. Xiao Jue protected with his sword and thought about the world. The two went from the alienation and temptation when they first met to the tacit understanding when they were side by side, and gradually fell in love in the shadow of the sword and the poison. When the sincerity of modern doctors collides with the responsibility of ancient princes, and when the secrets of Miao territory intersect with court disputes, can they gather together the rare objects to crack the strange poison? And can we protect the peace of mountains and rivers and the return of people's hearts amidst the turmoil?
