"Shanghai Old News: Heart Medicine Romance" combines the scientific paranoia of the old era with the glitz and glamor of Shanghai, and runs through the acquaintance of the male and female protagonists, shaping a duel between "science" and "human nature." Gu Zhaoshi's "eugenics" represents pseudoscience alienated by money and power, Bian Henian's "neurostimulation" represents cold pure science, and Gu Yizhi's "love and medical skills" represents the return of humanity and the ultimate cure. Lin Wanyin's final self-healing declared the victory of "heart" over "science".