Zhang Xiaonian, a young man from a remote mountain village, has been learning the family's "Mysterious Medicine Manual" and "Fire Sun Fist" from his grandfather since he was a child. Although he possesses unique medical and martial arts skills, he has been living a low-key and ordinary life because of his grandfather's instructions: "Don't reveal it easily until the moment of life or death." After his grandfather passed away unexpectedly, leaving behind a mysterious token and the last words to "go to Jiangcheng to find his old friend and protect the family's secret treasure", Zhang Xiaonian was forced to leave the mountain village and step into the prosperous but dangerous city.
When he first arrived in Jiangcheng, he repeatedly ran into obstacles because he didn't understand the city's rules. However, he relied on his superb medical skills to save the wealthy daughter Su Qingyue who was in crisis. From then on, he was involved in the whirlpool of business disputes and Jianghu forces. Faced with doubts about the authority of Western medicine, threats from underworld forces, and the covetousness of the mysterious ancient martial arts family, Zhang Xiaonian uses medicine as his blade and martial arts as his shield. While protecting the people around him, he gradually uncovers the truth behind his grandfather's death and the secret behind the family's treasure. He overcame obstacles all the way, growing from a boy in a mountain village to a master of medicine and martial arts who shocked the city. He saved lives with benevolence and benevolence, and defended justice with iron bones. In the end, he not only protected the family inheritance, but also carved out a world of his own in the city, composing a legendary chapter about passion, responsibility and protection.