This book is the representative work of Zhao Xianke, a physician in the Ming Dynasty. It consists of six volumes. It takes the "Mingmen Theory" as the core and runs through the academic thought of "kidney is the foundation of innateness". The book begins with "Picture Wings of the Nei Jing" and "Yin Yang Theory" to lay the theoretical foundation. Subsequent chapters discuss stroke, typhoid fever, miscellaneous diseases, gynecological diseases and other diseases. It advocates that "the treatment of diseases must be based on the root cause", emphasizing the fundamental treatment method of warming and nourishing kidney yang and nourishing kidney yin, and opposes the abuse of cold and cooling drugs. The book discusses in detail the physiological functions, pathological changes and relationship between "Mingmen" and the internal organs, and proposes flexible application methods of prescriptions such as "Liuwei Dihuang Pills" and "Bawei Dihuang Pills", closely integrating the Mingmen theory with clinical diagnosis and treatment. This book breaks through the traditional theoretical framework of viscera, enriches the basic theoretical system of traditional Chinese medicine, and has a profound influence on the development of kidney-tonifying treatment methods in later generations. It is an important classic for studying the Mingmen theory of traditional Chinese medicine and the clinical application of kidney-tonifying.