The story takes place in the year 305 New Year, when society has regressed and a super wealthy family with genes as its core has formed. Su Wan, the daughter of a former aristocrat, was forced to marry into the Gu family, the first aristocratic family, due to her family's bankruptcy. She became the wife of Gu Mingche, the frail heir who was about to be abandoned by the family. On her wedding night, she was almost involved in a carefully planned "accidental" murder.
Su Wan relied on his extraordinary observation skills and rigorous logical thinking to survive in the seemingly luxurious but murderous Gu family. She discovered that the Gu family's "house fight" was far from a simple fight for favor and power. Behind it was a shocking secret about genetic continuation. Core members of the family have died mysteriously due to "genetic diseases" one after another, but every death is full of doubts.
The highlight is that the core of this house fight is not traditional emotions and power, but a bloody competition around "perfect genes". Su Wan must join forces with the family's mysterious doctor Lu Chen to solve secret room murder cases one after another in a future mansion full of surveillance and genetic testing, and gradually uncover the cruel truth that the Gu family sacrificed relatives and even conducted illegal gene editing in order to maintain the purity of their bloodline. The whole process is highly suspenseful, with layers of twists and turns. In the end, Su Wan not only has to protect himself, but also exposes the sins of the twisted family to the public.