Shen Zhiwei was once the most valuable medical woman in Daliang. She used her family's "Rejuvenation Hand" to cut out her arm flesh as a guide, and stayed up for seven days to save the third prince who was dying of poisoning. She thought she would get a lot of honors and favors in exchange, but unexpectedly she attracted a wolf into the house. The concubine Shen Ruyan stole her medical skills to claim credit. In order to stabilize the political power, the third prince slaughtered the entire Shen family on the charge of "collaborating with the enemy" - his father's head was hung on nine gates for public display, his mother's bones were fed to wild dogs, and her three-year-old brother was ground into bone powder. She was given mute medicine, thrown into a dog cage, and died bitterly in the bite of a mad dog.
When she opened her eyes again, she was back to the day when the third prince was poisoned. The life-saving silver needle was hanging on her fingertips, and the sound of iron chains holding her father under house arrest could be heard outside the palace. This time, Shen Zhiwei put aside her kindness as a doctor and used silver needles to seal the poison without dispelling it, so as to gain three days of respite for herself. She burned all the authentic "Rejuvenation Hand" scrolls, forged fake prescriptions to induce the enemy to eat themselves, and even dripped the poisoned blood into the fifth prince's medicine bowl. Using the taboo technique of "poison and blood share fate", she tied the prince, who was regarded as a "sick man", onto a revenge chariot.
She used "dream talk" to force her concubine to reveal the truth about the family's destruction in public, used the "blood-drawing and burning evil" technique to expose the third prince's pseudo-dragon destiny to the public, and used the Northern Cavalry's troops to crush the imperial city. When the third prince collapsed on the throne with black blood pouring from his seven orifices, when the crazy concubine knelt down in a blood-stained phoenix robe and begged for mercy, and hung up a plaque of "Unknown Medical Clinic" in the ruined temple in the south of the city, she finally gained a new life.