In the century-old street of "Yunxi City", Su Qinghuan guards the old medicine shop "Qinghetang" passed down from his ancestors. She has a special ability - when she touches medicinal materials or old prescriptions, she can sense past memories related to them. One day, Dr. Lu Shiyan, a doctor of medicine, went to a drug store with an incomplete ancient prescription, hoping to restore the prescription and find out its source. This prescription actually allowed Su Qinghuan to see a fragment of the past between Lu Shiyan's great-grandfather and his great-grandmother. The two had worked together to develop a prescription to treat illnesses and save lives, but they parted ways due to a misunderstanding. As they recovered the prescription, Su Qinghuan and Lu Shiyan discovered that their families not only had a deep connection, but were also closely related to the "medical culture protection and development" storm that the ancient street was about to face. While they are digging into family secrets and stories behind prescriptions through medicinal materials and old objects, they are uniting with time-honored merchants in the ancient streets to fight against capital parties who want to commercialize and transform drug stores and destroy traditional medical culture in the name of development. In the process, the two went from strangers to familiarity, from fighting side by side to falling in love. In the end, they not only protected the medical culture of "Qinghetang" and the ancient street, but also solved family misunderstandings and allowed the traditional medical skills to be passed on.