Su Man'er, an orphan from the grassland, has outstanding medical skills and a vicious tongue. Nangong Ye, the eldest son, has unparalleled strength and possesses yandere. In order to escape, she broke into his hunting ground and he was seriously injured and fell into coma. She gave him acupuncture to save him. From then on, she was left in the Prince's Mansion to recuperate. The identity remains a mystery, undercurrents surge, assassins appear frequently, and court disputes arise. She uses poison to make medicine, uses wisdom to break situations, and saves him from danger many times. He protects his wife domineeringly and is extremely jealous, refusing to marry anyone but her. From an orphan girl to a royal concubine, from the frontier to the palace, husband and wife stand side by side and overcome the storm together. See how the poisonous doctor's little wife counterattacks the world!