Modern forensic pathologist Su Yunheng transmigrates to the Great Liang dynasty, where she becomes the foolish illegitimate daughter of the Marquis of Zhenbei's household. Poisoned by her stepmother from the start, she turns the tables using modern criminal investigation techniques and the legacy of the Wu Clan, awakening her identity as a Holy Maiden. The original owner of her body bore a forbidden Wu Clan art. To seal the longevity Gu of Imperial Preceptor Baili Wuya, she travels across the Five Continents with a spirit jade, sharing life-and-death trials with heir Baili Yu and the hidden guard Xiao Jingyan. As the spirit jade resonates, memories of a past life surge back: she is the reincarnation of the Wu Clan's Holy Maiden, bound to the Imperial Preceptor by a thousand-year bond. When all five jades unite to seal the Gu poison, she finally realizes that her true prison is the shackle of being the “Holy Maiden.” After plunging from a cliff, she is reborn through fire, shattering the spirit jade's restraints and breaking the deadlock with her pure soul. In the end, she escapes her fate and reunites with the one who has remained in her heart across two lifetimes, writing a story of redemption and growth spanning a thousand years.