Su Qingyuan, a top expert in modern medicine and poisoning, accidentally traveled through time and became the legitimate daughter of the Duke of Zhen. The original owner's biological mother died unjustly, and she was plotted by her vicious stepmother Liu Yuru. She was forced to celebrate the death of Prince Jing Xiao Jingyuan, who was riddled with poison and was about to die. In fact, she wanted to use the "failed wedding" to silence her.
In a desperate situation, Su Qingyuan used her exquisite golden needles and unique poison skills as bargaining chips to make a contract with the sinister and cold-hearted Xiao Jingyuan to "detoxify and change life." While using her medical skills, she used her medical skills to uncover the conspiracy of her stepmother to embezzle the dowry and poison her biological mother, clean up the spy agent installed by the queen in the palace, and win the hearts of the people through free clinics; at the same time, she detoxified and healed Xiao Jingyuan, from suppressing the poisonous blood to completely detoxifying, witnessing his transformation from a sickly prince in a wheelchair to a strong man who could hold a sword to protect her.
From being collaborators who tested each other, the two gradually developed feelings that no one else could interfere with. However, the queen and the prince were afraid that Xiao Jingyuan's recovery would threaten the imperial power, so they teamed up with Princess Rong to create trouble, and even staged a murderous plot during the flower viewing banquet in the palace. Faced with the hidden arrows in the court and the treacherous secrets in the backyard, Su Qingyuan used poisonous techniques to break the situation, and Xiao Jingyuan used his power to escort. In the end, she became the mother of Zhaoxue, and he eliminated the enemy party. This combination of "the poisonous doctor's legitimate daughter + the sinister prince" went from being a contracted couple to working side by side, guarding each other in the whirlpool of power and conspiracy, and living out their own strengths.