"People and Ghosts Take Different Paths: Love Breaks the Rules of the Three Realms" takes the pattern of the Three Realms as its bones and the deep love between humans and ghosts as its soul, unfolding a long epic scroll of fairy tales that spans a hundred years. Shen Qingci, the legitimate daughter of the Minister of Rites of Dajing, possessing a lunar physique and yin-yang eyes, met Xie Jingxing, a general who had been stranded in the netherworld for hundreds of years, in the music of the ancient house in Chang'an. He is the founding hero who died unjustly, and she is a gentle lady who hides her supernatural powers. A knot of hearts binds humans and ghosts, and half of the Three Life Stone bears witness to the entanglement of fate.
From staying together in the dark night on the streets of Chang'an to relying on each other for life and death on the banks of the Wangchuan River, they not only have to overturn a century-old injustice in the court and battle with treacherous officials and gangs; they also have to go deep into the seven and nine realms of the underworld to fight against the ancient evil spirit Mo Yuan who covets the Three Realms. When the Immortal Court wields the evil-killing blade in the name of "defying heaven", when the yin-yang barrier breaks down and evil spirits sweep across the world, the former weak lady awakens as a ferryman of yin and yang. The innocent general breaks free from the shackles of obsession and joins hands with Su Qingyao, the descendant of the magic family, and Yun Shu, the rebellious immortal official, to form an alliance between humans and ghosts to protect the peace of the two realms. The price of the three-life stone contract and the shackles of reincarnation fate, they use love as a blade and trust as a shield, vowing to carve out a way of life that "humans and ghosts can rely on" in the collision of the coldness of the nether world and the fire of the world.