Modern medical student Lin Wan transmigrates into the body of Shen Qinghe, an orphan girl in the prosperous Tang dynasty, and takes over her father's clinic to investigate the cause of his death. Using a blend of Chinese and Western medicine, she saves lives and exposes Prince Wang's scheme involving counterfeit medicine and poisonous sulfur. She joins forces with Xiao Jingyuan of the Imperial Guard to investigate the case, gets caught up in the power struggle between the Eastern Palace and the rebel forces in the northern deserts, and vows to protect Chang'an's peace and clear her father's name.