Su Qingyuan, director of modern emergency surgery, traveled through time and became the concubine of the Minister of Household Affairs of the Dajing Dynasty after a surgical accident. The original owner was madly in love with Prince Jing Xiao Yu, and even planned to frame others in order to marry him. However, on their wedding night, he was diagnosed with an "incurable disease" and was rejected by Prince Jing. He was thrown into another hospital to die.
Su Qingyuan relied on her superb medical knowledge to save herself, and accidentally discovered that the original owner's "terminal illness" was caused by artificial poisoning. In order to find out the truth, she walked around the market as a "folk medical woman", but she repeatedly met the cold-faced Prince Xiao Jue of Rui. This prince, who was rumored to be cruel and murderous and with disabled legs, always secretly helped her when she was in crisis.
As Su Qingyuan uses modern medical methods such as anatomy, first aid, and infectious disease prevention and control to solve strange cases (poisonings, plagues, and difficult childbirths), she gradually discovers that: Prince Jing's "affection" is a disguise, and the death of the original owner is his pawn to clear obstacles; and the seemingly cold Prince Rui is not only the "White Moonlight" doctor she regretted missing in her previous life, but also the only person who can see through the secret behind her medical skills and protect her. In the end, Su Qingyuan used medical evidence to expose Prince Jing's conspiracy and cure Prince Rui's leg disease. The two went from "testing each other" to "depending on each other for life and death" and staged a two-way redemption that spanned time and space.