Ethan Blackwood, a British nobleman who has wandered in the long river of time for 270 years, became immortal due to a mysterious curse. With his persistence for the truth, he shuttles through crime scenes as the chief medical examiner in modern times, using his extraordinary wisdom and experience to solve numerous mysteries, just to uncover the mystery of immortality. In this world full of modern technology and ancient secrets, he, together with his adopted son who knows his secrets, a resolute female police chief, and a fledgling female assistant who graduated from a higher education institution, jointly uncover the truth behind each of the thrilling murders.