Chen Xiao, a modern-day ER doctor, unexpectedly transmigrated into the body of a sixteen-year-old imperial physician with the same name in the fifteenth year of the Hongwu era. He was bound to the National Fortune Medical System. He arrived at the most dangerous moment in the Ming imperial court: Zhu Xiongying, the eldest legitimate grandson, and Empress Ma were both critically ill. With medical skills far beyond his time and help from the System, Chen Xiao pulled off an astonishing reversal and saved the two people most important to Zhu Yuanzhang. He was then drawn into the power struggles of the Ming Dynasty, beginning a legendary journey in which his medical skills would reshape the fate of the realm.