Chen Xiao, a modern emergency doctor, accidentally traveled back in time to a 16-year-old doctor with the same name and the same name in the 15th year of Hongwu in the Ming Dynasty, and was responsible for the "National Medical System". The place where he arrived was the most dangerous moment for the Ming Dynasty court - the eldest grandson Zhu Xiongying and Queen Ma were both critically ill. With medical skills and systematic assistance that transcended the times, Chen Xiao completed a shocking reversal and saved these two people who were crucial to Zhu Yuanzhang. As a result, he was involved in the power vortex of the Ming Dynasty, and began a legendary journey of stirring up the world with his medical skills.