Under the appearance of a hundred years of peace in the Dayan Dynasty, undercurrents are surging. A taboo picture called "Hundred Evil Pictures" that was thought to have been lost quietly reappeared. The evil spirits sealed in the picture began to follow people's desires and fears, triggering a series of unsolvable mysteries in the world.
In order to curb the spread of the vision, the imperial court secretly ordered the "Jingyesi" who specializes in dealing with supernatural events to conduct a thorough investigation. Shaoqing Shen Jiming, who was burdened with a blood feud, relied on his ability to "browse into the secluded world" to see into the moment of death. He teamed up with Wen Zhijie, a widower with superb skills and the ability to sense the "qi of death", to peel away the truth from the grotesque corpses. At the same time, the mysterious Taoist priest Lu Zhixuan, who is searching for the whereabouts of the "Hundred Evil Pictures", is protecting the girl Su Wanying who has the source of the disaster sealed in her body, slaying demons along the way.
When a strange "Painted Skin Bride" case brings the two teams together unexpectedly, they are shocked to realize that all the tragedies are not isolated cases, but a sign that the "Hundred Evils Picture" will soon break free of its seal and devour the world. The long night is approaching and ghosts are rampant. They must find a way to seal the scroll before the world becomes a paradise of ghosts. Otherwise, everyone will eventually become a new soul added to the painting.