In the 22nd year of the Republic of China, demon disasters occurred frequently in Jinghu County, Jiangnan: children were drained of their essence and blood, and corpses were hidden in the bride's sedan. All clues pointed to the destruction of the demon monument at Xuanqing Temple twenty years ago. Lin Zhaozhao, the last descendant of Xuanqing Temple, bears the blood feud of his parents who died tragically while guarding the monument. He carries a mahogany sword and amulet to trace the truth. Lu Chenzhou, a forensic reporter who studied abroad, did not believe in ghosts and gods, but because he witnessed a water demon capsize a boat and a bloody dog attack, he formed a strange partnership of "alchemy + science" with Lin Zhaozhao. The two work together to recover seven fragments of the demon-sealing stele, and fight against the powerful Song Sanye, who uses the blood of children to refine the "Blood Evil Bead", and the Japanese onmyoji Hideaki Fujiwara, who attempts to use the ancient demon "Nine Infants" to help the Japanese invade China. From the dying entrustment of the blind storyteller elder of the City God's Temple to the life-and-death test of Jiu Ying's decisive battle in Jinghu Mountain, they adhered to the original intention of "catching monsters is to save people" in the ups and downs of troubled times, and finally used their flesh and blood and faith to seal the monsters again, and also revealed the deep truth that "greed in the human heart is the most vicious monster."