Medical student Roland Villeroy accidentally fell into the plague purgatory of 1348. He was horrified to discover that the "Black Death" devouring Europe was actually the whisper of Cthulhu - a chaotic erosion called the "Entropy Plague." The "exorcism" of the Holy See is actually a "chaos ritual" that catalyzes corruption, and the isolation station in Venice is a weak "topological barrier." Carrying the strange "Plague Entropy Increaser" system, Roland rose up in despair. He used the medical knowledge of later generations to improve quarantine. In the chaos of Paris Medical College, he analyzed the laws of plague with subversive "chaos medicine" and touched the alchemical core regarded as taboo by the church - the "Stone of Entropy." When the ancient medical classic "Medical Integration" reveals the last hope against corruption - "negative entropy therapy", Roland must create a scar to protect humanity in the gap between faith and reason, in a desperate world surrounded by demons.
