Su Lingyue, the concubine of the prime minister's palace, entered the palace with her unique skills of poison medicine and accidentally activated the portable medical code left by her mother, which can identify hundreds of poisons and cure strange diseases. She was a low-level talent at the beginning, but was framed by her eldest sister Su Lingwei and Concubine Hua Guifei. She relied on the medical code to break the poison banquet and the anti-fascination potion, but they were thrown into the quagmire. When she met the cold-faced emperor Xiao Jingyuan, she used her medical skills to save the Queen Mother and quell the plague, and she was promoted step by step from the bottom of the talent list. It is difficult to guard against secret assassinations in the harem, so she protects herself with poisonous skills, saves others with her medical skills, and uncovers traitors. In the turbulent times in the court, she helps the emperor investigate corruption and put down rebellions, and even reveals the truth about the murder of her biological mother by her aunt. From a humble concubine to a poisonous queen, Su Lingyue used medicine as her blade and wisdom as her shield to carve out a splendid future within the palace walls, and share the power of the country with Xiao Jingyuan.