Su Qingyan, the concubine of the prime minister's house, was framed by her aunt Li Shi, her aunt Su Jinxiu and the prince Xiao Jinyuan in her previous life. She had her eyes gouged out and her hands cut off, and she died tragically in the cold palace. Once reborn, she returned with the "Heaven-Defying Medical Sutra", with superb medical skills and a tough mind. Poisoned by the aunt? She identified and detoxified the poison and turned an army against her; her sister-in-law stole the marriage? She set up a trap to ruin her reputation; was the prince framed? She used her strength to discredit him. Unexpectedly, she met Xiao Che, the regent who held military power. She used her medical skills as a bargaining chip to help him cure hidden diseases and pursue great careers, while he shielded her from wind and rain and protected her. Fighting in the house, the treacherous harem, and the intrigues in the court, Su Qingyan worked step by step, relying on her wisdom and medical skills to tear apart her enemies, counterattack and become the winner of the palace fight, and even joined hands with the regent to compose a conspiracy love legend.