Three years after the virus broke out, the once prosperous city has been reduced to ruins infested by zombies, and humans are struggling to survive in the cracks. Lu Jingshen, a former virology researcher at the Centers for Disease Control and Prevention, lived in seclusion in an abandoned laboratory with guilt and trauma because he failed to prevent his sister from being infected with the virus, trying to decipher the secrets of the zombie virus. In an accident, he rescued a team of survivors who were being hunted by high-level zombies and was forced to step out of the closed world. This team, composed of retired special forces, hacker girls, and old-school doctors, is looking for the legendary "Source Crystal" that can resist viruses. Lu Jingshen discovered that the zombies had undergone strange mutations, and there seemed to be traces of human manipulation behind them. The truth about his sister's infection and the shady story of the virus leak were actually related to the mysterious biological company "Creation". In the crisis of survival and the test of human nature, Lu Jingshen led his team to deal with bloodthirsty zombies and hostile survivors while pursuing the antidote to the virus and the truth of the incident. Not only did he have to face his inner nightmare, but he also had to shoulder the heavy responsibility of rebuilding the hope of mankind on the road to saving others and self-salvation.