In the 1930s, Shanghai was experiencing great changes. Su Jinse, a surgeon who returned from studying abroad, returned to his hometown to find out the truth about his father's mysterious death, but was involved in a secret war between the Hongmen, the Green Gang and the Japanese secret service. She reunites with Gu Qianfan, who was once her childhood sweetheart but is now the young master of Hongmen. She has a difficult choice between the hatred of the country and the family and the love of her children. When the artillery fire of the Battle of Songhu tore through the night sky, Su Jinse discovered that her father's death was actually related to a shocking secret concerning the survival of the country. She must adhere to the benevolence of a doctor in the bloody romance, protect the national justice in the whirlpool of conspiracy, and use the scalpel and wisdom to write the legendary epic of beauty in troubled times.