During the Xuande period of the Ming Dynasty, bizarre murders occurred one after another in Shuntian Mansion in the capital. The deceased died in strange ways and had a special rouge button beside them. During the investigation of the case, Shen Yan, a policeman who is cold and taciturn but solves cases like a god, unexpectedly meets Su Qinghuan, a female doctor with a cheerful personality, proficient in medical science and good at observing details. The two initially distrusted each other and frequently "quarreled" with each other, but later had to work together as clues in the case continued to intertwine. Relying on their respective expertise, they peeled off the cocoon and uncovered the conspiracy behind the case step by step. From the brothel mystery in the bustling capital, to the nursery rhyme curse case in a remote town, to the theft of royal tribute, every case has hidden mysteries, involving complex interpersonal relationships and unknown secrets. In the process of solving the case, Shen Yan gradually opened up his closed heart, and Su Qinghuan also realized the growth from "medicine" to "medicine the world". In the end, the two not only uncovered the mastermind behind the scenes, but also protected the peace of the people, becoming a legendary "detective partner" in the Ming Dynasty.
