During the Xuande period of the Ming Dynasty, strange things happened frequently in the capital. First, the daughter of the Minister of Civil Affairs disappeared mysteriously on her wedding day, leaving only a blood-stained rouge button; then, a prisoner in Shuntian Mansion died suddenly in the middle of the night, and the circumstances of his death were exactly the same as an unsolved case ten years ago. Lu Zhao, the official of Jinyiwei, relies on his keen observation and strong logical reasoning ability. During the investigation process, he accidentally met Su Qingmei, a folk woman who is proficient in pharmacology and good at disguise. From the initial mutual testing and mutual distrust, the two later developed a tacit cooperation and worked together to investigate the case, gradually uncovering the conspiracy behind the case. As the investigation deepened, they discovered that these seemingly isolated cases were inextricably linked to the "Old Donglin Case" ten years ago, and the forces behind all this were trying to shake the foundation of the Ming Dynasty. In the midst of many crises, Lu Zhao and Su Qingmei not only have to solve the ensuing mysteries, but also have to avoid the pursuit in the dark, and also face the complex emotions in their hearts. Can they protect justice in troubled times and let the truth be revealed to the world?