During the Kaiyuan period of the Tang Dynasty, under the prosperous times, evil spirits secretly emerged.
In the ghost market of Chang'an, on a rainy night, a complete human skin appeared, with the flesh and bones inside missing. Pei Zhiqiu, a female official of Dali Temple who does not believe in ghosts and gods, is ordered to investigate the case, but she encounters the mysterious Taoist priest Li Xuan who possesses a rare treasure and asserts that this is not the work of human beings.
One is a court official who believes in legal evidence, and the other is a half-demon fighter who walks on the edge of yin and yang. The two people, who were supposed to be incompatible, were forced to work together due to a series of strange cases. One of them relies on Taoism and magic, the other relies on logical reasoning. In the process of solving the case, they gradually get closer to a shocking conspiracy that attempts to overthrow the dynasty - the mysterious organization "Painted Skin" is collecting "evil thoughts" in the world in an attempt to release the ancient "demon ancestor".
The true secrets of Li Xuan's restless half-demon bloodline and the magic weapon "Hundred Demons Scroll", and the truth about the old case of Pei Zhiqiu's father being wronged have also gradually come to light with the investigation...
In the prosperous age of Chang'an, humans and monsters coexist; mysterious cases occur frequently, and fateful confrontations occur.
When reason encounters the supernatural, when the law faces demonic hearts, can they defend the world in the whirlpool of conspiracy?