Jiang Shuyue, the daughter of an imperial physician, was brought into the palace as a maid because her father was wronged. She relied on the ancestral "Five Luck and Six Qi Acupuncture" to save the Queen Mother, but was framed. The tyrant Xie Xuanjin forced her to be his exclusive "needle maid" in the name of investigating the secret case of the previous dynasty. The two secretly fell in love while getting along to heal their headaches and stubborn illnesses, but they were involved in a conspiracy to restore the country by the remnants of the previous dynasty. Imperial Physician Wen Run made Wen Biehe an orphan from the previous dynasty, and used Jiang Shuyue's obsession to find out the truth to sow discord between the emperor and the concubine. When Xie Xuanjin cut off his arm to save her, Jiang Shuyue realized his deep feelings and worked together to smash the power conspiracy between Wen Biehe and Queen Mother Zhou Huiyin. They revolutionized the imperial court with medical skills and finally became the first queen to take charge of the imperial hospital since the founding of the People's Republic of China.