It tells the story of Shen Jinghong, who has a family feud, and Su Muyan, who is looking for his missing master. Their fates are intertwined because of their common enemy, the Blood Shadow Hall.
Three years ago, Shen Jinghong's father Shen Xiaolin was killed by people from the Blood Shadow Hall, leaving only half of the broken jade pendant, and the other half was taken away by the murderer. In order to avenge his father, Shen Jinghong concealed his name and studied swordsmanship with an old Taoist in the Qinling Mountains for three years. Then he entered the world, vowing to find out the truth.
Su Muyan is a disciple of the doctor Su Changfeng. His master disappeared mysteriously three days ago, leaving traces of a fight at the scene. She suspects that this matter is related to the Blood Shadow Hall, which has been committing crimes frequently in Jiangnan recently. Before his disappearance, the master was cryptic about a mysterious ancient medical book and mentioned a "shattering conspiracy", which made Su Muyan determined to find out.
In the guest building outside Lin'an Mansion, Shen Jinghong was chased by the Blood Shadow Hall. When he came to rescue him, he met Su Muyan who was pursuing the Blood Shadow Hall. Before his death, the shopkeeper gave Shen Jinghong a wooden sign engraved with the word "Su" to guide him to find Mr. Su in the west of the city. Mr. Su was Su Muyan's missing master.
The two discovered that each other's goals were related. Half of Shen Jinghong's jade pendant was similar to the complete jade pendant that Su Muyan had seen in his master's study. Su Changfeng's disappearance seemed to be inseparable from the ancient medical book. The Blood Shadow Hall's power spreads all over the south of the Yangtze River, and their pursuit follows closely. Shen Jinghong and Su Muyan decide to go together to face the dangers of the world, uncovering the secrets of the Blood Shadow Hall, the truth about Shen's father's murder, and the conspiracy behind Su Changfeng's disappearance.