Liu Xiaohu, a doctor who traveled through time and space, used his modern medical knowledge and keen insight to get involved in a series of mysterious cases in Chang'an of the Tang Dynasty. Starting from the time when Song Renyi colluded with Tai Hospital to falsify medicinal materials and framed Zhongliang, he gradually uncovered the intertwined conspiracy between the palace and the market: Concubine Wei secretly replaced the prince and poisoned Concubine Chen for power. Song Zhiyuan's former ministry colluded with the Japanese war faction to create the murder of Qiandao Ying. They also used vinegar workshops to secretly mint counterfeit coins and use Tibetan magic to refine weapons with star sand, in an attempt to use foreign forces to disrupt the government and seize power.