Liu Shuying, a folk doctor, rescued Xiao Che, the cold-faced prince, who was poisoned by a strange poison on a snowy night, and discovered that the poison that caused the incident spread through the Ren and Du lines. She took "The Collection of Cleansing Wrongs" as a guide, skillfully applied golden needles, and supplemented it with strange medicines, and struggled to detoxify amid doubts from the Imperial Hospital. In order to find out the mastermind behind the palace poisoning, the two teamed up: she relied on "tongue diagnosis" and "pulse diagnosis" to gain insight into the disguised illness, and used poison to fight poison to prepare a prescription; he gave him the authority to build a "poison sample library" and co-authored the "Palace Poison Classic". From tit-for-tat confrontation to life-and-death support, they worked step by step to break through the confusion and set up the "Medical Women's Toxic Testing Department" to let the light of traditional Chinese medicine's toxicology illuminate the darkest corners of the palace. It is not a matter of force and robbery, but equal emphasis on medical skills and resourcefulness. A relationship begins with the grace of saving a life and becomes a love of life and death with the same goals.