In the Chu Dynasty, King Rui Xiao Yichen, who had great military exploits, was poisoned by a strange poison and was said to have only three days left to live. The imperial edict granted marriage, but the Prime Minister's Office did not want his legitimate daughter to marry a dying man, so he pushed his concubine Su Miaoling out to marry him instead. Su Miaoling, a medical girl who was neglected in a deep house but possessed unique skills, married into Prince Rui's palace with her medical skills and unwillingness to face her fate.
On their wedding night, facing the dying King Rui, she did not accept her fate. With her superb medical skills, she discovered that the poison poisoned by King Rui was complicated, but she also saw a glimmer of hope. Just when she was trying her best to rescue, the assassin attacked. At the critical moment, the jade pendant left by her mother burst out with magical power, helping her escape into the mountains with King Rui.
From then on, Su Miaoling evaded the pursuit of all forces while detoxifying King Rui to save his life. She used her medical skills to resolve crisis after crisis, and gradually fell in love with King Rui while getting along. Behind King Rui's poison, there seems to be palace secrets and a huge conspiracy hidden. Can these ill-fated men and women change their fate despite many difficulties, so that the prince who only has three days left to live can live for a hundred years, work together to uncover all the mysteries, and write a legendary story?