Suning, a master of modern Chinese medicine, transformed into the "waste" legitimate daughter who was mistreated in the Yongning Hou Mansion. When she opened her eyes, she encountered a poisonous plot. She relied on her medical skills to save herself, and vowed to find out the cause of the original owner's death and seek justice.
In the deep house, her aunt is ruthless and her concubine is hypocritical. She works every step of the way, using needles as blades and medicine as a plan to tear away the illusion of tenderness in the Marquis. Above the court, she encounters the regent Rong Jingxing, who is disabled by poisoning and has been framed to seize power.
"You detoxify me, and I'll protect you." A deal closely connects the fate of the two. He is a cold-faced prince who holds great power in the government, taking off his armor in front of her to protect her from the whirlpool of house fighting; she is a rejuvenating medical expert who cuts out poisons and heals his wounds, and accompanies him in the abyss of intrigue to explore the truth.
From the backyard of the Hou Mansion to the imperial palace, from testing each other to relying on life and death, they join hands to fight against the royal conspiracy and uncover the shocking secret behind the bone-eroding poison. When medical skills meet political skills, when feelings of revenge are intertwined, let's see how she uses her medical skills to determine the world, how he uses his power to seek peace in the world, and finally, holding hands side by side, they control thousands of miles of rivers and mountains.