Su Wantang, the daughter of a medicine farmer in Lingzhi Village, was jealous of her eldest sister because she was born with a body that was "invulnerable to all poisons", and she was framed for poisoning the clan elders. In desperate situations, she activates the "Negative Emotion System" - absorbing other people's negative emotions such as malice and fear towards her, which can be exchanged for the remaining volumes of "The Book of One Hundred Poisons" to unlock the ability to resist poisons. She first used rudimentary poison identification skills to prove her innocence, and backhandedly uncovered the conspiracy of her eldest sister to collude with a poisoner from another village to poison; later, she used the "Poison Transformation Technique" redeemed by the system to refine the antidote to save a beggar who was suffering from a strange disease, and became famous; finally, in the medicine examination, she used the high-level medicine The "Poison Control Realm" resolved the poisonous mist of the thousand-year-old snake king, and was accepted as a personal heir by the head of the Medicine Sect. It was also unexpectedly discovered that the system fragments were related to the "Lingshu Jade" that his mother had disappeared that year, and that his co-worker Gu Yan, who had been secretly helping him, was actually the secret guard tracking down the real culprit who poisoned his mother.