During the Yongxi period of the Qi Dynasty, Su Wanzhao, the legitimate daughter of the Zhenguo General Palace, was selected into the palace as the queen because of her superb medical skills. However, she was framed by the noble concubine Shen Yurong for murdering the third prince, and was thrown into the cold palace by the emperor Xiao Chengyu. In the cold palace, she relied on her superb medical skills to detoxify the poisonous porridge, assassins and other assassins. She even accidentally rescued the Queen Mother who was poisoned by Shen Yurong, and gained the support of the Queen Mother to walk out of the cold palace. After that, she used "motherwort to break the false pregnancy" to expose Shen Yurong's conspiracy, and used "silver hairpin to test the poison" to expose concubine Li Zhaoyi's frame-up plan, and gradually disintegrated the enemy forces in the harem. At the same time, she discovered that the death of the third prince involved the conspiracy of the emperor's younger brother Xiao Chengan to seize the throne, and Xiao Chengyu's helpless compromises to consolidate imperial power. In the end, she used her medical skills to save Xiao Chengyu from danger, brought down Xiao Chengan, and revealed all the truth. In order to make up for Xiao Chengyu's abdication, she became the regent mother, took control of the imperial power, and gained true love with Xiao Chengyu.
