Su Jiuli, a wandering orphan girl, was accepted as a handyman drug boy by Qingming Sect Yaofeng. She accidentally touched the ruined monument at the gate of the sect and awakened the "Nine Poison Exquisite Body" and the inheritance of "Ten Thousand Poisons Immortal Sutra". She first used poisonous dew to cure the strange cold poison disease of Elder Yaofeng, and then in the sect competition, she amazed the audience with the magic trick of "poisonous mist trapped enemies + antidote to save lives", slapping her eldest sister Su Qingyuan in the face who had previously laughed at her. The young sect leader Xie Lang had long been attracted by the soft heart hidden under her poisonous skills. He secretly helped her block all the plots by sending her spiritual cakes every day on the pretext of "testing the poison", and finally put the concentric lock that had been hidden for three years on her wrist at the medicine peak filled with poisonous flowers.