Shi Yanqing, a cutting-edge restorer from the National Palace Museum Cultural Relics Restoration Institute, was repairing a damaged ancient Ming Dynasty painting "Ming Xianzong's Pleasure Picture" in accordance with the "minimum intervention principle". He accidentally discovered that the cinnabar pigment on the clothes of the characters in the painting contained abnormally distributed highly toxic arsenic elements. Its distribution pattern is surprisingly consistent with the symptoms of chronic poisoning recorded in the Southern Song Dynasty's holy book of forensic medicine, "The Collection of Cleansing Wrongs". In order to solve this four-hundred-year-old suspense, she teamed up with Jiang Ji, a rigorous but slightly "eccentric" forensic evidence expert, to use X-ray fluorescence spectroscopy and other techniques to uncover the hidden poisoning route map and detoxification secrets in ancient paintings such as cloud patterns and lotus cuffs. Under the double shackles of "restoration ethics" and "evidence timeline", they used technology as an edge and logic as a bridge. They not only restored the truth of the deep palace drug case, but also promoted the establishment of the "Cultural Relics Crime Forensic Appraisal Center", turning silent cultural relics into unique witnesses of historical justice.