In 2077, a mysterious virus called "entropy" suddenly broke out. It devoured life at an alarming rate and dragged the world into the abyss of doom. The city was reduced to ruins, order was gone, and the surviving humans were lingering in the shadow of the virus. Ma Engyao lost his close relatives when the virus broke out. He was also infected by the virus but miraculously did not mutate completely. Relying on his extraordinary technological capabilities, he established "Laboratory Zero" on the ruins, trying to combat "entropy" by analyzing the genetic code of the virus and developing high-tech equipment. He is struggling to move forward in a doomsday world full of danger and betrayal. He not only has to face the terrifying mutants spawned by the virus, but also the covetousness and threats of other survivor forces. Whether he can find the key to reconstruct the world in the doomsday of increasing entropy and become the last hope of mankind is still unknown.